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Case 148. BK virus infection of bladder (30 y-o F)
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| Incidental autopsy findings of the urinary bladder in leukemia case 3 months after bone marrow transplantation |
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Key words : BK virus, cystitis
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opportunistic infection
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| Amphophilic intranuclear inclusion bodies are seen in the urothelial cells (HE). Inflammation is scarcely observed. Refer also to case 14. | Electron micrograph of the intranuclear inclusion of the urothelial cell in a paraffin section confirmed infection of small-sized viral particles, consistent with papova virus. | |
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| Reference case 148A Urine cytology in case of SLE (22 y-o F) receiving corticosteroid. Poorly cohesive urothelial cells possess amorphous and smudgy nuclei, indicative of BK viral infection. The "decoy cells" should be distinguished from cancer cells. |
Reference case 148A Restaining of the cytology specimen for VP-1 antigen of SV-40, showing an antigenicity common to the papova viruses (left: Papanicolaou, right: immunostaining). VP-1 antigen of the papova virus is strongly expressed in the urothelial cells with nuclear inclusions. |
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| Reference case 148A Electron micrograph of the urine sediment. The nucleus of the urothelial cell possesses 50 nm-sized small viral particles. |
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