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Case 230. Rheumatic fever (6 y-o M)
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Autopsied heart in a Kenyan boy who died of acute cardiac failure
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Key words : rheumatic fever, Aschoff nodule, Anitschkow cell
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| Aschoff's nodule seen in the edematous interstitium of the heart (HE). The spindle cells with basophilic cytoplasm are called Anitschkow cells having a catapillar-shaped nucleus. | The nuclei of Anitschkow cells in the Aschoff's nodule possess catapillar-shaped in the longitudinal section or owl-eyed in the cross section (HE, high power). | |
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| Features of rheumatic valvulitis showing accumulation of Anitschkow cells and lymphocytes in the hyaline stroma (HE). Antibody to tonsillitis-provoking group A Streptococcus is cross-reactive to the human heart-related antigen. | Reference case 230A Anitschkow cells in non-rheumatic heart of 22 y-o female (HE). Anitschkow-type interstitial cells with catapillar nuclei are not specific to rheumatic heart disease. They are occasionally seen in the normal fetal and adult hearts. |
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