Case 17. Whipple's disease (52 y-o M)

       
  Duodenal biopsy from a patient suffering from a long-standing intractable diarrhea and protein-losing enteropathy  
       

 

  Strong PAS reactivity seen in the foamy macrophages accumulated in the lamina propria mucosae (PAS). This represents intracellular proliferation of Tropheryma whippeli