Case 50. Leishmania donovani infection (Kala azar) (54 y-o M)

　 　 　 　
　 Liver biopsy from a Japanese worker who stayed in India, showing prolonged fever and liver dysfunction 　
　 　 　 　

　

 　 The 1:500 diluted patien's own serum detects granular (round-shaped) pathogens in the cytoplasm of macrophages in the microgranulomas, strongly suggesting visceral leishmaniasis (indirect immunoperoxidase). The diagnosis was confirmed serologically.