Case 125. Acanthamebic meningoencephalitis (60 y-o M)

       
  Brain biopsy from highly edematous right hemisphere in case of alcoholic liver cirrhosis manifesting left hemiparesis (HIV: negative)  
       

 

  The perivascular macrophage-like cells with centrally situated karyosome, embedded in the chronic inflammatory background, correspond to the trophozoites of free-living ameba (HE, oil immersion).