Case 125. Acanthamebic meningoencephalitis (60 y-o M)

       
  Brain biopsy from highly edematous right hemisphere in case of alcoholic liver cirrhosis manifesting left hemiparesis (HIV: negative)  
       

 

  Another view demonstrates a smaller, round-shaped cell with eosinophilic cytoplasm, a round nucleus and wrinkled, double-layered cyst wall (HE, oil immersion). A cyst form of free-living ameba is indicated.