Case 142. HPV-6 infection (condyloma acuminatum) (22 y-o F)

       
  Cervical smear and biopsy from a sexually active woman with polypoid lesions in the uterine cervix  
       

 

  HPV, type 6/11 genome-reactive intranuclear particles measure about 20 nm, much smaller than mature HPV viral particles (50-60 nm). Together with the paucity of capsid antigen expression, it is likely that the viral genome is distributed as an episome (naked DNA) in the nucleus.