Case 143. HPV-16 infection (severe dysplasia) (38 y-o F)

　 　 　 　
　 Cervical smear and biopsy from a sexually active woman with colposcopic abnormality 　
　 　 　 　

　

 　 Restaining of the bleached pap smear (in situ hybridization for HPV, type 16 genome) shows dot-like reactivity in the nucleus of some dyskaryotic cells.