Case 143. HPV-16 infection (severe dysplasia) (38 y-o F)

       
  Cervical smear and biopsy from a sexually active woman with colposcopic abnormality  
       

 

  HPV, type 16 genome-positive location in severe dysplasia ultrastructurally corresponds to part of chromatin, indicative of the integration of the oncogenic viral DNA into host cell DNA (pre-embedding method for in situ hybridization using a paraffin section).